Deadpool: The Saga of Wade Wilson #1

In trying to grow his middle finger back in front of his merc buddies, Deadpool is deeply embarrassed when he finds out that he can't do it. Black Tom taunts Deadpool by sending him the glove from the hand he removed (in the 2nd Deadpool limited series) and Deadpool collects Siryn so the two can head off to take down her evil uncle. Instead they find Killebrew, one of the doctors who created Deadpool for Weapon X, and he explains that Deadpool’s faulty healing factor is due to the fact that he is dying.