ISAAC
About ISAAC in comics
ISAAC first appeared in Iron Man #54 (1972), published by Marvel.
We list 38 comic series featuring ISAAC, with series dates from 1946 to 2026, from publishers including Marvel, Dark Horse, DC.
The key issues below cover ISAAC's first appearance, origin and death issues where the record exists, plus other key issues they appear in.
ISAAC key issues
- First appearanceIron Man #54 (1972) - Marvel
Also Appears In
The Avengers
The Crush
The Mighty World of Marvel
Sunday Pix
Lab Rats
The Thanos Imperative
She-Hulk
True Believers: Infinity Gauntlet
Fantastic Four
The Darkness
Iron Man
Green Lantern
JLA: Classified
Abe Sapien
The Orville
West Coast Avengers Omnibus
Sir Edward Grey, Witchfinder: Lost and Gone Forever
The Kids' Cartoon Bible
Harrow County
Hercules
Avengers vs. Thanos
Cla$war
The Mighty World of Marvel
Ka-Zar
Infinity Gauntlet
The Orville Library Edition
G.I. Joe
The Life of Joseph Visualized
Solo
The Orville Season 2.5: Launch Day
The Magdalena
The Mark
The Orville Season 1.5: New Beginnings
Naked Cannibal Campers
Guardians of the Galaxy
Green Lantern / Green Arrow
The Orville Season 2.5: Digressions
Thanos: The Infinity Siblings